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  • 20 November 2020 01:48

Downstream Processing Drive US$ 49.67 Bn Market by 2027

According to Precedence Research, the global downstream processing market size is expected to reach over USD 49.67 billion by 2027.

The global downstream processing market was valued at around USD 17.87 billion in 2019 and predicted to register a compound annual growth rate (CAGR) of around 13.65% during period 2020 to 2027.

A steady increase in the demand for recombinant products or drug quality has driven the adoption of downstream processing. The rise in the penetration of the biologics and large molecules is anticipated to drive the adoption of downstream methodologies.

Key Trends

First and foremost, increasing demand for biosynthetic products for secondary application in pharmaceutics is the key factor driving the downstream processing market. At present, naturally sourced pharmaceuticals are increasingly witnessing demand due to their low risk of side-effects. Downstream processing enables recovery and purification of biosynthetic products from natural sources such as plant or animal tissue or fermentation broth. For example, downstream processing is a key step in the manufacture of antibiotics such as penicillin. The process involves purification and separation of antibiotics from a range of mediums.

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Downstream processing is applied in the commercial scale manufacture of monoclonal antibodies. Antibodies therapies generally involve long-term use of antibodies in substantial dose, because of which biopharmaceutical companies employ downstream processing for commercial scale production.

Furthermore, downstream processing is employed in the commercial production of biological products. Some of these biological products are vaccines for small pox and influenza. Downstream processing is used in the industrial production of enzymes. These enzymes find applications in food preservation and food processing that have commercial value.

On the flip side, high cost of equipment for downstream processing and lack of trained personnel to conduct the process are limiting the growth of downstream processing market to some extent. In addition, purification bottleneck and lack of single-use options are some other factors challenging the downstream processing market.

Report Highlights

The chromatography segment dominated the overall downstream processing market in 2019. The key players provide integrated and safe solutions that work efficiently during the vital steps of process development to production scale.

Antibiotic production accounted for the largest revenue share in 2019. Antibiotics are used in the treatment of a number of conditions from cancers to infectious diseases.

Antibodies production segment is expected to witness the fastest CAGR in the market for downstream processing throughout the forecast period.

Purification by chromatography dominated the overall market for downstream processing in 2019 and the solid-liquid separation segment is expected to witness the fastest CAGR in the coming years. Chromatography by separation is used during the separation and purification of the highest value products.

North America region dominated the market for downstream processing with the largest revenue share in 2019 owing to government support for the promotion of bioprocess technologies, a significant rise in medical expenditure, and the presence of robust healthcare infrastructure.

Asia Pacific is expected to register the fastest growth rate in the market for downstream processing due to the rising investments by developers and consumers in the field of biotechnology.

Geographical Analysis

The global downstream processing market could be spread across North America, Asia Pacific, Europe, Latin America, and the Middle East and Africa. As per the report findings, North America and Europe are established markets for downstream processing. These regions being long-established centers of scientific research make them key regions for downstream processing.

However, Asia Pacific is likely to present new growth opportunities to players in the downstream processing market. Factors such as increasing demand for biopharmaceuticals and increasing R&D initiatives in the biopharmaceutical industry are indirectly spurring the downstream processing market in the region.

The report sheds light on various aspects and answers pertinent questions on the market. Some of the important ones are:

1. What can be the best investment choices for venturing into new product and service lines?

2. What value propositions should businesses aim at while making new research and development funding?

3. Which regulations will be most helpful for stakeholders to boost their supply chain network?

4. Which regions might see the demand maturing in certain segments in near future?

5. What are the some of the best cost optimization strategies with vendors that some well-entrenched players have gained success with?

6. Which are the key perspectives that the C-suite are leveraging to move businesses to new growth trajectory?

7. Which government regulations might challenge the status of key regional markets?

8. How will the emerging political and economic scenario affect opportunities in key growth areas?

9. What are some of the value-grab opportunities in various segments?

10. What will be the barrier to entry for new players in the market?

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Prominent market participants operating in the downstream processing industry are mentioned below:

  • BoehringerIngelheim
  • Danaher Corporation
  • Sartorius Stedium Biotech S.A
  • GE Healthcare
  • Merck Millipore
  • Eppendorf AG
  • 3M Company
  • Thermo Fisher Scientific Inc
  • Finesse Solutions Inc
  • Lonza Group

Market Segmentation

By Product

  • Centrifuges
  • Dryers
  • Chromatography Systems
  • Filters
  • Evaporators
  • Others
By Application
  • Antibodies Production
  • Antibiotic Production
  • Hormone Production
  • Enzyme Production
  • Vaccine Production
By Technique
  • Purification by Chromatography
  • Solid-liquid Separation
    • Centrifugation
    • Filtration
  • Cell Disruption
  • Concentration
  • Formulation
By Regional Outlook
  • North America
    • U.S.
    • Canada
  • Europe
    • U.K.
    • Germany
    • France
  • Asia Pacific
    • China
    • India
    • Japan
    • South Korea
  • Middle East & Africa
  • Latin America

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